Cerebrolysin contains low molecular weight biologically active neuropeptides, which penetrate the blood-brain barrier and enter directly to the nerve cells. Organ-specific drug has multimodal action on the brain, i.e. It provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.
Metabolic regulation: Cerebrolysin drug increases the efficiency of aerobic energy metabolism of the brain, improves intracellular protein synthesis in the developing and aging brain.
Neuroprotective effect: the drug protects neurons from damaging effects of lactic acidosis, prevents the formation of free radicals, improves perezhivayemost and prevents neuronal death in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effects of excitatory amino acids (glutamate).
Neurotrophic Activity: drug Cerebrolysin - only peptidergic nootropic drug with proven neurotrophic activity similar to the action of natural factors of neuronal growth (NGF), but manifests itself in a peripheral administration.
Functional Neuromodulation: the drug has a positive effect in disorders of cognitive functions, improves concentration, memory processes.
It belongs to their neuroprotective agents, complex drugs with neurotrophic activity proposed for use in the treatment of patients with various neurological diseases, such as ischemic and haemorrhagic stroke, vascular dementia, including Alzheimer's disease. It is a complex of low molecular weight peptides, obtained via enzymatic cleavage of purified proteins medulla pigs. The active fraction is presented peptides, the molecular weight does not exceed 10,000 daltons. Due to the complex nature cerebrolysin exact mechanism of action remains unknown.
Status epilepticus, acute renal failure, hypersensitivity to the drug.
V / m (5 ml) / w (10 mL) in / by slow infusion (10 to 50 ml).
Dose and duration of treatment depends on the nature and severity of the disease and the patient's age. Possible to assign single doses, which may reach the magnitude of 50 ml, but more preferably, a course of treatment. The recommended optimal course of treatment - daily injection for 10-20 days.
Acute conditions (ischemic stroke, head trauma, complications after neurosurgical operations) - from 10 to 50 ml.
The residual period of stroke and traumatic damage to the brain and spinal cord - from 5 to 50 ml.
Psycho-organic syndrome of depression and - from 5 to 30 ml.
Alzheimer's disease, vascular dementia and Alzheimer's combined-vascular origin - from 5 to 30 ml.
In practice neyropediatricheskoy - 0.1-0.2 ml / kg.
To improve the effectiveness of the treatment can be carried out repeated courses, until there is improvement in the patient following treatment. After the first dose rate frequency assignment may be reduced to 2 or 3 times a week.
Doses of 10 to 50 ml is recommended to enter only through slow in / in infusion after dilution proposed standard solutions for infusion. The duration of infusion was 15 to 60 min.
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Mastodynon 100ml drops